A positive result means HLA-B27 was found in your blood. You may have a higher-than-average risk of certain autoimmune diseases, such as ankylosing spondylitis and reactive arthritis. If you are white, you are more likely to test positive for the HLA-B27 antigens.
Bad days make me want to stay in bed, especially when I can barely put socks on. Those days remind me to move it or lose it.
Ankylosing spondylitis can run in families, and the HLA-B27 gene can be inherited from another family member.
Researchers aren’t sure what triggers AS, but they think it’s tied to your genes. Most people with AS have a gene that makes a protein called HLA-B27. Doctors think it tells your immune system to attack some common bacteria in your body and sets off AS symptoms.
1.Physical therapy and education 2. Medications 3.Surgery
The precise underlying cause of ankylosing spondylitis is unknown, but it is believed to have a strong genetic component, and possibly an environmental one. Most individuals who have ankylosing spondylitis have a gene variation called HLA-B27.
Secukinumab, an IL-17a inhibitor currently approved in the United States for moderate to severe plaque psoriasis, psoriatic arthritis and ankylosing spondylitis, has been approved by the U.S. Food and Drug Administration for the treatment of active non-radiographic axial spondyloarthritis (nr-axSpA).
This is undoubtedly exciting news for ankylosing spondylitis patients who have suffered from back pain for many years. If gene editing technology can cure beta thalassemia and sickle cell disease, then gene editing technology treats ankylosing spondylitis also has certain feasibility. I just don’t know if the cost of treatment is affordable for most patients.